Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity
نویسندگان
چکیده
منابع مشابه
Absence of RNase H allows replication of pBR322 in Escherichia coli mutants lacking DNA polymerase I.
rnh (formerly termed sdrA) mutants of Escherichia coli K-12, capable of continuous DNA replication in the absence of protein synthesis (stable DNA replication), are devoid of ribonuclease H (RNase H, EC 3.1.26.4) activity. Plasmid pBR322 was found to replicate in rnh mutants in the absence of DNA polymerase I, the polA gene product, which is normally required for replication of this plasmid. Th...
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ژورنال
عنوان ژورنال: Genetics
سال: 2015
ISSN: 1943-2631
DOI: 10.1534/genetics.115.182725